A/C Enzymatic HCY Assay
The Only Single Enzyme HCY Assay
Applicable to Common Automatic and Portable Analyzers


A/C Diagnostics LLC
7917 Ostrow Street, San Diego, CA 92111 USA 
Telephone: (858)654-2555;  E-mail: all@anticancer.com
Patents
A/C Diagnostics has patents covering all aspects of the A/C Enzymatic Homocysteine Assay:
US Patent Nos. 5,985,540, 5,998,191, 6,066,467, 6,140,102, 6,468,762, 6,448,446, 6,713,273.
Japanese Patent No. 3,337,693. European Patent No. 1,265,846. Australia Patent No. 758,729,
229,460 and Chinese Patent # 98807531.8.
References
McCully KS. Homocysteine and vascular disease. Nat.Med.1996;2:386-89.

Nurk E, Tell GS, Vollset SE, Nygard O, Refsum H, Ueland PM.  Plasma total homocysteine and hospitalizations for cardiovascular disease: the Hordaland Homocysteine Study.  Arch. Intern. Med. 2002;162:1374-81.

Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M., and Vollset SE, Plasma homocysteine levels and mortality in patients with coronary artery disease.  N. Engl. J. Med.1997;337:230-36.

Han Q, Lenz M, Tan Y, Xu M, Sun X, Tan XZ, Tan XY, Tang L, Miljkovic D, and Hoffman RM. High expression, purification and properties of recombinant homocysteine, a, g-lyase.  Protein Expression and Purification 14, 267-274, 1998. 

Tan Y, Sun X, Tang L, Zhang N, Han Q,Xu M, Tan XZ,Tan XY, Hoffman RM. Automated Enzymatic Assay for Homocysteine. Clinical Chemistry 49, 1029-1030, 2003.

Tan Y, Tang L, Sun X, Zhang N, Han Q, Xu M, Baranov E, Tan XZ, Tan XY, Rashidi B, An Z, Perry AW, Hoffman RM.  Total-homocysteine enzymatic assay. Clinical Chemistry 2000;46:1686-1688.

Tan Y. and Hoffman R.H., A highly-sensitive single-enzymatic homocysteine assay, Nature protocols, Vol 3 N9, 1388-94, Aug 6 2008.

A/C HCY Assay is suitable for clinical routine testing, new born screening and animal studies.